Pilomatricoma in a case of familial xeroderma pigmentosum.

The patient was one of the three affected siblings, born of a second degree consanguineous marriage in a family with four children. While the eldest sister was unaffected, the patient’s second sister and a younger brother were similarly afflicted by the disease. Subsequently on a four-year follow-up, the patient developed multiple cutaneous tumors on the face simultaneously, which included a conjunctival squamous cell carcinoma, a pigmented basal cell epithelioma on the nose and a malignant melanoma on infraorbital area. The brother too, had developed multiple cutaneous malignancies and died at the age of 15 years, due to the spread of the tumors.